Topiramate, Serum

Test Code: TD_5955

CPT Code(s): 80201

$29

Test Details

Alternative Name(s)

Topamax

Test Includes

Topiramate

Methodology

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Rejection Criteria

Samples collected in serum separator tube

Reference Range(s)

2.0-20.0 MCG/ML

Specimen Requirements

Preferred Specimen

Plain red top tube

Minimum Volume

0.2 mL serum or plasma

Sample Stability

3 days room temperature
2 weeks refrigerated
1 month frozen

Transport Temperature

Refrigerated

Collection Instructions

Allow sample to clot in an upright position for at least 60 minutes, then centrifuge sample and transfer serum to a plastic transport tube within 2 hours of collection. Clearly label tube as serum from a plain red top tube. Refrigerate.
Note: Ideal sampling time for all antiepileptic drugs is immediately before the next oral dose (trough). If this is not possible, patients should not be advised to delay their scheduled dose for longer than 2-3 hours. Sample collection and the time that the medication was last ingested should be noted on the requisition.

Alternative Specimen

1 mL EDTA (lavender top) plasma. Centrifuge sample and separate plasma from cells within 2 hours of collection. Transfer plasma to a plastic transport tube. Clearly label tube as EDTA or heparin plasma. Refrigerate. Note: Ideal sampling time for all antiepileptic drugs is immediately before the next oral dose (trough). If this is not possible, patients should not be advised to delay their scheduled dose for longer than 2-3 hours. Sample collection and the time that the medication was last ingested should be noted on the requisition.